| Below is a list of the players who were drafted and/or played on the professional level after leaving SIUE. If you feel a name is missing from this list, contact SIUE Sports Information. | |
| Player | Played for or Drafted By |
|---|---|
| Mike Jones | Sporting Kansas City |
| Mike Banner | Chicago Fire |
| Zach Bauer | AC St. Louis |
| Bruce Bellinger | Minnesota (MISL) |
| Rick Benben | Atlanta |
| John Berner | Colorado Rapids |
| Justin Bilyeu | New York Red Bulls (MLS) |
| Bob Bozada | Minnesota |
| Chris Cacciatore | Rochester |
| Jeff Cacciatore | Ft. Lauderdale |
| Steve Cacciatore | Rochester |
| Chris Carenza | San Antonio |
| John Carenza | St. Louis |
| Tim Clark | Minnesota |
| Greg Crook | St. Louis Ambush |
| Chris Damico | Kansas City |
| John Deinowski | St. Louis Stars |
| Dave Delphus | Minnesota |
| Mark Downar | St. Louis Stars |
| Don Ebert | New York |
| Lewis Ellis | Bodens BK (Sweden) |
| Vince Fassi | Dallas |
| Tom Galati | Philadelphia |
| Ed Gettemeier | Kansas City (MISL) and Montreal (NASL) |
| Brian Groark | St. Louis Ambush |
| Tim Groark | St. Louis (MISL) |
| Tim Guelker | Buffalo |
| Tom Henson | St. Louis Stars |
| Brian Higgins | Indianapolis |
| Joe Howe | Atlanta |
| Kevin Howe | Atlanta |
| Tom Howe | St. Louis Stars |
| Dave Hummert | Los Angeles |
| Chris Hundelt | St. Louis Steamers |
| Dave Hundelt | Houston |
| Kevin Hundelt | St. Louis Steamers |
| Mike Kelley | Dallas |
| Peter Kelly | Saint Louis FC |
| Bobby Kessen | Dallas |
| Kent Kobernus | Saint Louis FC |
| Andy Korbesmeyer | St. Louis Ambush |
| Chester Kowalewski | Denver |
| Brett Lane | F.C. Linkoping (Sweden) |
| Todd Lauer | St. Louis Ambush |
| Austin Ledbetter | Saint Louis FC (USL) |
| Tim Loughman | Louisville Thunder (AISA) |
| Matt Little | St. Louis Ambush |
| Greg Makowski | Colorado |
| Scott Marty | St. Louis Ambush |
| Matt Malloy | Phoenix (MISL) |
| Dan McManemy | St. Louis Knights |
| Justin McMillian | St. Louis Ambush |
| Gene Mishalow | Washington |
| Mark Moran | Kicks |
| Sean Mulqueeny | St. Louis Steamers |
| Dan O'Keefe | Kansas City (MISL) |
| Matt Polster | Chicago Fire |
| Joe Reiniger | St. Louis Ambush |
| Addae Rique | St. Louis Steamers |
| Bob Robson | Atlanta |
| Darren Snyder | St. Louis Ambush |
| Bill Stallings | St. Louis Ambush (MISL) |
| John Stone | Wichita (MISL) |
| Tom Stone | St. Louis Knights (USISL Pro) |
| John Stremlau | Dallas |
| Cal Thomas | St. Louis Steamers |
| Steve Trittschuh | St. Louis (MISL) |
| Jason Turkington | Lafayette Swampcats (EISL) |
| Mike Twellman | St. Louis (MISL) |
| Tim Twellman | Stars |
| Tom Twellman | Stars |
| Greg Villa | Kicks |
| Christian Volesky | Rochester Rhinos/ Saint Louis FC (USL) |
| John Zacheis | Detroit Express (NASL) |
